Franchise X meets Franchise Y has long been a mainstay of fan art and fan fiction. Sometimes the link is obvious, while others take a bit more creativity to put together. Mass Effect and Hollow Knight certainly seem like the latter category, one being a AAA shooter and the other a 2D indie platformer. However, at least one artist found a way to make it work.
Fan artist leafjuly took to Twitter to share their interpretation of how some Mass Effect characters would look in the insectoid world of Hollow Knight. Another user later uploaded the image to the Mass Effect subreddit, though moderators later removed the post.